Principles are principles but money talks.
http://www.nytimes.com/2015/04/24/us/politics/at-new-york-reception-ted-cruz-is-said-to-strike-different-tone-toward-gays.html?_r=0
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The vote was 56-43. Ten Republicans voted for her including Majority Leader Mitch McConnell.
You will note that the votes add up to 99. There are, of course, 100 Senators. You would never guess who didn't bother to show up to vote.
http://thehill.com/blogs/floor-action/senate/239878-senate-votes-to-confirm-lynch-as-attorney-general